
What is methylated seed oil? Methylated seed oil (MSO) is a specialized adjuvant used in agriculture to enhance the performance of herbicides, insecticides, and fungicides. Derived from natural seed oils such as soybean, canola, or sunflower, MSO undergoes a chemical process called methylation, which transforms it into a highly effective surfactant. This process involves esterifying fatty acids in the seed oil with methanol to create methyl esters, improving solubility, reducing viscosity, and enhancing compatibility with various agricultural chemicals. In this article, we’ll explore the science behind methylated seed oil, its benefits, applications, and why it’s a go-to choice for farmers and gardeners aiming to optimize pest and weed control.
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Understanding Methylated Seed Oil
Methylated seed oil is an oil-based surfactant designed to improve the efficacy of post-emergence herbicides, which are applied to weeds after they’ve sprouted. Unlike traditional crop oil concentrates (COCs) that rely on petroleum-based oils, MSO is derived from renewable seed oils, making it a more environmentally friendly option. The methylation process modifies the oil’s structure, enabling it to dissolve the waxy cuticle on plant leaves, allowing pesticides to penetrate more effectively. This results in faster and more efficient absorption of active ingredients into the target plant, enhancing weed control and reducing the need for higher pesticide doses.

MSO typically contains a blend of methylated seed oil and emulsifiers, which help it mix seamlessly with water-based spray solutions. Products like Southern Ag Methylated Seed Oil and LESCO MSO are formulated to provide rapid penetration, improved adhesion, and resistance to evaporation, ensuring that pesticides remain effective even in challenging conditions like high temperatures or low humidity.
How Methylated Seed Oil Works
The primary role of methylated seed oil is to act as a “sticker” and penetrant, ensuring that pesticides adhere to plant surfaces and penetrate the leaf’s waxy cuticle. Here’s how it works:
- Enhanced Penetration: MSO dissolves the waxy layer on plant leaves, allowing herbicides to enter plant tissues more effectively. This is particularly useful for systemic herbicides that need to be absorbed and translocated within the plant to disrupt its physiological processes.
- Improved Spreadability: MSO reduces the surface tension of spray solutions, enabling droplets to spread evenly across leaf surfaces. This ensures comprehensive coverage, minimizing untreated areas where weeds or pests could persist.
- Increased Adhesion: MSO helps spray solutions stick to plant surfaces, even in adverse conditions like rain or wind, reducing runoff and improving efficacy.
- Reduced Evaporation: By slowing the drying of herbicide droplets, MSO extends the time available for active ingredients to be absorbed, which is critical in hot, dry climates.
Research conducted by the China Agricultural University demonstrated that 0.3% MSO enhanced the efficacy of the herbicide topramezone by 1.5-fold on giant foxtail and 1.0-fold on velvetleaf. The study found that MSO reduced solution surface tension, increased droplet spread, and decreased the formation of herbicide crystals on leaf surfaces, leading to better absorption.
Benefits of Using Methylated Seed Oil
Methylated seed oil offers several advantages for farmers, landscapers, and gardeners:
- Improved Pesticide Performance: MSO enhances the effectiveness of herbicides, insecticides, and fungicides, potentially reducing the amount of chemical needed for effective control. This can lead to cost savings and a lower environmental footprint.
- Versatility Across Crops: MSO is compatible with a wide range of crops, including grains, fruits, vegetables, and ornamental plants, making it a versatile tool for diverse agricultural needs.
- Environmental Benefits: Derived from renewable seed oils, MSO is biodegradable and poses minimal health risks to humans and the environment compared to synthetic surfactants.
- Enhanced Weed Control: MSO is particularly effective against weeds with thick, waxy cuticles or those under stress from drought, ensuring reliable control even in challenging conditions.
- Water Efficiency: By improving adhesion and reducing evaporation, MSO helps conserve water by minimizing the need for excessive spraying.
Applications of Methylated Seed Oil
Methylated seed oil is used in various agricultural and horticultural settings:
- Post-Emergence Herbicides: MSO is commonly paired with herbicides like quinclorac, mesotrione, and topramezone to control broadleaf weeds and grasses. It enhances penetration, making it ideal for tough weeds like crabgrass or velvetleaf.
- Fungicides and Insecticides: MSO improves the coverage and penetration of fungicides and insecticides, ensuring effective treatment against fungal diseases and insect infestations.
- Defoliants and Desiccants: In crops like cotton, MSO enhances the performance of defoliants and desiccants, aiding in leaf drying for mechanical harvesting.
- Turf and Ornamental Plants: Landscapers use MSO to maintain pristine lawns and gardens, ensuring herbicides target weeds without harming desirable plants.
How to Use Methylated Seed Oil
To maximize the benefits of methylated seed oil, follow these tips:
- Follow Label Instructions: Always check the herbicide label for recommended MSO rates, typically 1–4 pints per acre or 1 teaspoon per gallon of spray solution, not exceeding 5% v/v.
- Mix Properly: Fill the spray tank 2/3 with water, add the herbicide, then mix in MSO to ensure even distribution. Avoid overmixing to prevent foaming.
- Apply Evenly: Use a hose-end sprayer, backpack sprayer, or spray rig to apply the mixture uniformly across the treatment area.
- Avoid Aquatic Areas: MSO is not labeled for aquatic applications, so avoid using it near water bodies to prevent environmental harm.
- Store Safely: Keep MSO in a resealable container to prevent spills and store it away from children and pets, as it can cause skin and eye irritation if mishandled.

Comparing Methylated Seed Oil to Other Adjuvants
what is methylated seed oil Methylated seed oil is often compared to crop oil concentrates (COCs) and non-ionic surfactants (NIS). Here’s how it stacks up:
- MSO vs. COC: COCs are petroleum-based and effective for grasses and waxy leaf surfaces, but MSO outperforms in cooler weather and with systemic herbicides due to its natural oil base and enhanced penetration.
- MSO vs. NIS: MSO is stickier and more aggressive in dissolving leaf wax, leading to faster herbicide absorption compared to NIS, which is less effective on tough weeds.
Environmental and Safety Considerations
what is methylated seed oil While methylated seed oil is biodegradable and derived from renewable sources, it’s not without risks. It can cause skin and eye irritation and is harmful if swallowed or inhaled. Always wear protective gear during application and keep MSO out of reach of children and pets. Its environmental impact is lower than synthetic surfactants, but care should be taken to avoid overuse or application near aquatic ecosystems.
Real-World Example: Transforming a Lawn with MSO
Consider a homeowner battling crabgrass in a Zoysia lawn. By mixing LESCO Methylated Seed Oil with quinclorac, they achieved superior weed control. The MSO ensured the herbicide adhered to the waxy crabgrass leaves, penetrating deeply and eliminating the weeds within weeks. The lawn transformed into a lush, weed-free oasis, demonstrating MSO’s ability to enhance herbicide performance.
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Frequently Asked Questions About Methylated Seed Oil
- What is methylated seed oil used for?
what is methylated seed oil Methylated seed oil is used as an adjuvant to enhance the performance of post-emergence herbicides, insecticides, and fungicides by improving penetration, spreadability, and adhesion on plant surfaces. - How does methylated seed oil differ from crop oil concentrates?
MSO is derived from natural seed oils and undergoes methylation for better solubility and penetration, while COCs are petroleum-based. MSO is more effective with systemic herbicides and in cooler weather. - Can methylated seed oil be used with all herbicides?
MSO is compatible with many post-emergence herbicides like quinclorac and topramezone, but always check the herbicide label to ensure compatibility and recommended rates. - Is methylated seed oil safe for the environment?
MSO is biodegradable and derived from renewable seed oils, making it more environmentally friendly than synthetic surfactants. However, it should not be used near aquatic areas. - How much methylated seed oil should I use?
Typical rates are 1–4 pints per acre or 1 teaspoon per gallon of spray solution, not exceeding 5% v/v. Follow the herbicide label for specific instructions.